LA3349C-DCU-CFT for the Supply, Delivery, Installation, Commissioning and Calibration of Correlative Optical Tweezers-Fluorescence System

Description

Dublin City University (DCU) request the supply, delivery, installation, commissioning and calibration of a Correlative Optical Tweezers-Fluorescence System. The correlative optical tweezers-fluorescence system will be a keystone asset in DCU's research inventory. The instrument will combine optical tweezers and fluorescence microscopy for detailed measurement, visualisation and analysis of biomolecular behaviour. The system will enable a detailed study of small molecule interactions with macromolecular substrates, including nucleic acids, peptides, and lipids, specifically allowing for force measurements indicative of stability and conformation, while also providing microscopy confirmation of conformational changes, binding, and/or other perturbations. Such data will facilitate the development of new therapeutics at DCU.