Virtual-Integrated Twin for Autonomous Lifesaving (VITAL)

Tender summary

UPDATE: The purpose of Amendment 1 to DARPA-PS-26-26, the Virtual-Integrated Twin for Autonomous Lifesaving (VITAL) Program Solicitation (PS), is to clarify the proposal abstract questions deadline and the 7-page proposal abstract section requirements. <br/><br/>The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative approaches to address challenges in developing continuously updating digital twin models of the cardiovascular system that combine patient data with biological physics to simulate in real time possible interventions and to predict their outcomes before actual intervention on a patient. The VITAL program will establish a foundation for causal, prediction-driven decision support in medicine, enabling clinicians and future autonomous systems to evaluate treatment options before they are applied. By defining when mechanistic digital twins, reduced-order models, and data-driven inference are reliable and actionable, VITAL will shift medical care from reactive assessment to anticipatory intervention. This capability has the potential to improve outcomes across acute, chronic, and emergent clinical settings. Solicitation Number: DARPA-PS-26-26 Type: Solicitation Base Type: Solicitation NAICS: 541714 Classification Code: AC12 Response Deadline: 2026-06-25T16:00:00 Office Address: ARLINGTON, VA POC: Dr. Roozbeh Jafari, Program Manager, DARPA/BTO, VITAL@darpa.mil

What to check before bidding

• Located in United States.
• Source notice 3e66d960c0a14d51b236bbcf712d34cf on SAM.gov.
• Notice published 21 Apr 2026; Tenqual indexed it 23 Apr 2026.
• Deadline listed as 25 Jun 2026.
• 5 tender documents identified.
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